18 research outputs found
Versatile Graphene-Based Platform for Robust Nanobiohybrid Interfaces
Technologically useful and robust graphene-based interfaces for devices
require the introduction of highly selective, stable, and covalently bonded
functionalities on the graphene surface, whilst essentially retaining the
electronic properties of the pristine layer. This work demonstrates that highly
controlled, ultrahigh vacuum covalent chemical functionalization of graphene
sheets with a thiol-terminated molecule provides a robust and tunable platform
for the development of hybrid nanostructures in different environments. We
employ this facile strategy to covalently couple two representative systems of
broad interest: metal nanoparticles, via S-metal bonds, and thiol-modified DNA
aptamers, via disulfide bridges. Both systems, which have been characterized by
a multi-technique approach, remain firmly anchored to the graphene surface even
after several washing cycles. Atomic force microscopy images demonstrate that
the conjugated aptamer retains the functionality required to recognize a target
protein. This methodology opens a new route to the integration of high-quality
graphene layers into diverse technological platforms, including plasmonics,
optoelectronics, or biosensing. With respect to the latter, the viability of a
thiol-functionalized chemical vapor deposition graphene-based solution-gated
field-effect transistor array was assessed
Bronchoscopist's perception of the quality of the single-use bronchoscope (Ambu aScope4™) in selected bronchoscopies: a multicenter study in 21 Spanish pulmonology services
Background: The disposable bronchoscope is an excellent alternative to face the problem of SARS-CoV-2 and other cross infections, but the bronchoscopist's perception of its quality has not been evaluated.
Methods: To evaluate the quality of the Ambu-aScope4 disposable bronchoscope, we carried out a cross-sectional study in 21 Spanish pulmonology services. We use a standardized questionnaire completed by the bronchoscopists at the end of each bronchoscopy. The variables were described with absolute and relative frequencies, measures of central tendency and dispersion depending on their nature. The existence of learning curves was evaluated by CUSUM analysis.
Results: The most frequent indications in 300 included bronchoscopies was bronchial aspiration in 69.3% and the median duration of these was 9.1 min. The route of entry was nasal in 47.2% and oral in 34.1%. The average score for ease of use, image, and aspiration quality was 80/100. All the planned techniques were performed in 94.9% and the bronchoscopist was satisfied in 96.6% of the bronchoscopies. They highlighted the portability and immediacy of the aScope4TM to start the procedure in 99.3%, the possibility of taking and storing images in 99.3%. The CUSUM analysis showed average scores > 70/100 from the first procedure and from the 9th procedure more than 80% of the scores exceeded the 80/100 score.
Conclusions: The aScope4™ scored well for ease of use, imaging, and aspiration. We found a learning curve with excellent scores from the 9th procedure. Bronchoscopists highlighted its portability, immediacy of use and the possibility of taking and storing images
Bronchoscopist's perception of the quality of the single-use bronchoscope (Ambu aScope4™) in selected bronchoscopies: a multicenter study in 21 Spanish pulmonology services
Background: The disposable bronchoscope is an excellent alternative to face the problem of SARS-CoV-2 and other
cross infections, but the bronchoscopist’s perception of its quality has not been evaluated.
Methods: To evaluate the quality of the Ambu-aScope4 disposable bronchoscope, we carried out a cross-sectional
study in 21 Spanish pulmonology services. We use a standardized questionnaire completed by the bronchoscopists at
the end of each bronchoscopy. The variables were described with absolute and relative frequencies, measures of cen‑
tral tendency and dispersion depending on their nature. The existence of learning curves was evaluated by CUSUM
analysis.
Results: The most frequent indications in 300 included bronchoscopies was bronchial aspiration in 69.3% and the
median duration of these was 9.1 min. The route of entry was nasal in 47.2% and oral in 34.1%. The average score for
ease of use, image, and aspiration quality was 80/100. All the planned techniques were performed in 94.9% and the
bronchoscopist was satisfed in 96.6% of the bronchoscopies. They highlighted the portability and immediacy of the
aScope4TM to start the procedure in 99.3%, the possibility of taking and storing images in 99.3%. The CUSUM analysis showed average scores>70/100 from the frst procedure and from the 9th procedure more than 80% of the scores
exceeded the 80/100 score
Avances en Informática y Automática. Octavo Workshop
[ES]El Máster Oficial en Sistemas Inteligentes de la Universidad de Salamanca tiene como principal objetivo promover la iniciación de los estudiantes en el ámbito de la investigación. El congreso organizado por el Departamento de Informática y Automática que se celebra dentro del Máster en Sistemas Inteligentes de la Universidad de Salamanca proporciona la oportunidad ideal para que sus estudiantes presenten los principales resultados de sus Trabajos de Fin de Máster y obtengan una realimentación del interés de los mismos. La octava edición del workshop “Avances en Informática y Automática”, correspondiente al curso 2013 - 2014, ha sido un encuentro interdisciplinar donde
se han presentado trabajos pertenecientes a un amplio abanico de líneas de investigación,
desde los sistemas multiagente, la visualización de la información o la minería de datos hasta la lógica, el reconocimiento de patrones o las redes neuronales. Todos los trabajos han sido supervisados por investigadores de reconocido prestigio pertenecientes a la Universidad de Salamanca, proporcionando el marco idóneo para sentar las bases de una futura tesis doctoral. Entre los principales objetivos del congreso se encuentran: ofrecer a los estudiantes un marco donde exponer sus primeros trabajos de investigación.
Proporcionar a los participantes un foro donde discutir ideas y encontrar nuevas
sugerencias de compañeros, investigadores y otros asistentes a la reunión. Permitir a cada estudiante una realimentación de los participantes sobre su trabajo y una orientación sobre las futuras direcciones de investigación. Contribuir al desarrollo del espíritu de colaboración en la investigación
International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures
Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries
Structure and magnetic anisotropies of epitaxial FePd (0 0 1) and (1 1 0) alloys
Epitaxial FePd thin films are obtained by sputtering deposition on MgO(1 0 0) and (1 1 0) substrates. In both orientations, it is found that growth temperature strongly affects crystalline structure of the films, namely both degree of chemical order and residual strain. As a consequence, by selecting the appropriate crystalline orientation and growth conditions, structures exhibiting strong uniaxial in plane or perpendicular magnetic anisotropy are fabricated.Peer reviewe
EnerVMAS: Virtual Agent Organizations to Optimize Energy Consumption Using Intelligent Temperature Calibration
International audienc